24/7 Barrier Balance Cream
Your skin's barrier is what keeps moisture in and irritants out. When it's compromised, everything suffers: dryness, sensitivity, redness, faster aging. This cream doesn't just hydrate the surface. It works with your skin's own repair system to rebuild the barrier from within, while defensin peptides support deep renewal underneath.
Why PRO Exclusive?The PRO Exclusive formulation features an enhanced concentration of Age-Repair Defensins® peptides not available in our retail formulation, paired with deep hydration and barrier support. In the Fabi/Taub 2023 peer-reviewed clinical study, this enhanced concentration was shown to support visible improvement in both the surface and deeper layers of the skin. Available only through your provider's office.
What Are You Experiencing?
If any of these sound familiar, your skin barrier is asking for help. The 24/7 Barrier Balance Cream was made for exactly this.
Persistent dryness
Your skin feels tight, flaky, or rough no matter how much moisturizer you use. Products sit on top instead of absorbing. The dryness keeps coming back.
Deep multi-layer hydrationDamaged barrier
Your skin stings when you apply products. It reacts to things that never used to bother you. The protective layer that keeps your skin healthy has been compromised.
Barrier rebuild with oleosomesSensitivity and redness
Rosacea-prone skin flares. Redness that won't calm down. Skin that's reactive, uncomfortable, and hard to soothe. You need something that calms instead of irritates.
Anti-inflammatory botanical complexWrinkles deepening
Fine lines turning into real wrinkles. Skin losing its bounce. The cream you're using hydrates the surface but isn't doing anything about the aging underneath.
Defensin peptides support renewalDull, tired-looking skin
Your skin has lost its glow. It looks flat and washed out even when you feel rested. The luminosity you had in your 20s is gone.
Brightening with niacinamidePost-procedure recovery
Your skin needs support after a treatment. It's red, sensitive, and needs hydration without irritation. The wrong product can set recovery back.
Safe for post-procedure useMore than a moisturizer
Most creams simply coat the surface with moisture that evaporates within hours. The 24/7 Barrier Balance Cream delivers patented defensin peptides that support your skin's own renewal process underneath the hydration layer. You get immediate comfort and long-term structural improvement at the same time.
What Patients Are Seeing
The 24/7 Barrier Balance Cream is a core part of the DefenAge PRO Exclusive regimen tested in peer-reviewed clinical studies published in the Journal of Drugs in Dermatology.
Fabi S, Taub AF. Journal of Drugs in Dermatology. 2023;22(9). 20 subjects, 90-day protocol, IRB-approved (NCT05082766). Regimen: DefenAge PRO Exclusive 8-in-1 BioSerum, 24/7 Barrier Balance Cream, 3D Eye Radiance Cream, 1-Step Multi-Cleanse. Individual results may vary.
"Improvements were noted in all aspects of skin quality including wrinkles, laxity, pigmentation, texture, and radiance."— Fabi, Taub et al. Journal of Drugs in Dermatology, 2023
See the Difference
Photographs from the 2018 multicenter, double-blind, vehicle-controlled clinical trial published in the Journal of Drugs in Dermatology (Taub AF et al.). 44 subjects enrolled, 42 completed the 12-week protocol. No filters. No retouching.
Individual results may vary. Photos taken under consistent lighting conditions by independent clinical evaluators. Patients used the full DefenAge regimen daily for 12 weeks.
Not Just Another Moisturizer
Most creams coat the surface. This one supports renewal underneath.
Deep hydration that actually lasts
Moisture that absorbs into your skin instead of sitting on top. Shea butter, hyaluronic acid, and plant-based oils deliver hydration at every level. You'll feel the difference for hours, not minutes.
Calms redness and sensitivity
A natural soothing complex helps reduce the appearance of redness and irritation without steroids. Safe for rosacea-prone skin, sensitive skin, and post-procedure recovery. Your skin feels comfortable, not just covered.
Renews while it hydrates
Contains the same patented defensin peptides as our 8-in-1 BioSerum, supporting your skin's own renewal process underneath the hydration layer. You get immediate comfort and long-term improvement at the same time.
Full Ingredient List — 24/7 Barrier Balance Cream PRO
▾Simple. Three Steps. Morning and Night.
Cleanse
Start with 1-Step Multi-Cleanse to gently remove debris and prepare your skin.
Morning & eveningMoisturize with Barrier Balance Cream
Apply 1-2 pumps to your face. If using Eye Cream or Neck Cream, apply those now too. Wait 30 seconds before the next step.
You are here — this stepFinish with BioSerum
1-2 pumps on your face. Always the last step. Eight serums in one, delivering the highest defensin concentration in the line.
Always last — completes your routineReady to Rebuild Your Barrier?
The 24/7 Barrier Balance Cream PRO Exclusive is available only through authorized medical aesthetic providers. Find one near you to start restoring your skin's foundation.
Pairs Perfectly With
Bestseller8-in-1 BioSerum
Eight serums in one. The highest defensin concentration in the line. Always applied last.
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1-Step Multi-Cleanse
The first step. Melt away everything in one luxurious cleansing step.
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3D Eye Radiance Cream
Targets crow's feet, puffiness, and dark circles. Apply at Step 2 with this cream.
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KitClinical Power Trio
BioSerum + Barrier Balance Cream + Masque. The recommended starting point.
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