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BestsellerPlatinum EditionStep 3 — Apply Last

Platinum Edition

8-in-1 BioSerum

Your skin hasn't forgotten how to look its best.

Lines getting deeper. Tone getting duller. Pores looking larger. You're not imagining it. The 8-in-1 BioSerum works with your body's own renewal system to visibly reverse the signs you're seeing, without irritation. First changes visible in six to twelve weeks.

Wrinkles & fine linesDark spotsLarge poresLoss of firmnessDull skinRednessUneven textureCrepey skin

Recommended for

All skin typesSensitiveRosacea-prone skinMelasmaPost-procedure

1

2

3

Applied last — after cleanse and cream Why is BioSerum the last step?

Why PRO Exclusive?The PRO Exclusive formulation features an enhanced concentration of Age-Repair Defensins® peptides, not available in our retail formulation. In the Fabi/Taub 2023 peer-reviewed clinical study, this enhanced concentration was shown to support visible improvement in both the surface and deeper layers of the skin. Available only through your provider's office.

Patented

Clean

Results in weeks

1.5 fl oz (45 ml)

Is this for you?

What Are You Seeing in the Mirror?

If any of these sound familiar, the 8-in-1 BioSerum was made for exactly what you're experiencing.

Wrinkles and fine lines

Crow's feet deepening. Forehead lines that don't go away when you stop squinting. Lines around your mouth that weren't there five years ago.

Visible improvement in 82% of patients

Dark spots and uneven tone

Sun damage showing up as brown patches. Melasma that won't fade. Skin that used to be one even tone now looks blotchy.

Visible improvement in pigmentation

Large pores and rough texture

Pores that seem to grow every year. Skin that feels bumpy instead of smooth. Texture you can see even through foundation.

100% saw reduction of deep pores

Loss of firmness

Skin that doesn't bounce back. Jawline losing its definition. That feeling that everything is starting to slowly sag.

Renewed elasticity in clinical study

Dullness and lost radiance

Your skin used to glow. Now it looks flat, tired, and washed out, even when you're well-rested. The luminosity is gone.

100% saw improved skin evenness

Redness and sensitivity

Rosacea-prone skin flares. Skin that reacts to everything. Products that burn or sting. You need results but can't tolerate retinol.

Safe for rosacea-prone and sensitive skin

Tired of choosing between results and comfort?

The BioSerum delivers anti-aging results comparable to retinol without the irritation, peeling, or sun sensitivity. Safe for sensitive skin, rosacea-prone skin, melasma, and all Fitzpatrick skin types. No adjustment period. No redness. Just results.

Clinical proof

The Numbers Don’t Lie

Published, peer-reviewed results from a multi-center, double-blind, vehicle-controlled (placebo-controlled) clinical trial. 44 subjects enrolled, 42 completed, 12 weeks of evaluation by independent clinical graders.

100%

saw deep pore reduction

100%

saw improved skin evenness

82%

reported wrinkle reduction

73%

saw oiliness minimized

Results based on the 12-week treatment arm of the cited study. Individual results may vary.

“I expect that patients may respond to the DefenAge PRO Exclusive products faster; improvement may be observed at higher levels, and we may see a wider range of results.”

— Amy Forman Taub, MD, Board-Certified Dermatologist — Lead Investigator

Study photography

See the Difference

Photos taken during the 2018 JDD study under consistent lighting conditions by independent clinical evaluators. Subjects used the full regimen (2-Minute Reveal Masque, 24/7 Barrier Balance Cream, 8-in-1 BioSerum) over 12 weeks. No filters. No retouching.

Overall skin renewal

Patient 22

Taub et al., JDD 2018 — 12 weeks, full regimen

Wrinkles & fine lines

Clinical grading scale

Taub et al., JDD 2018 — 82% saw visible reduction

Pores & texture

Clinical grading scale

Taub et al., JDD 2018 — 100% saw deep pore reduction

Firmness & radiance

Patient 10

Taub et al., JDD 2018 — 12 weeks, full regimen

Photos taken under consistent lighting conditions by independent clinical evaluators during the 2018 JDD study. Individual results may vary.

Citation: Taub AF, Bucay VW, Keller GS, Williams JA, Mehregan DR. A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Tolerability of a Skincare Regimen Containing Defensin-Molecules. J Drugs Dermatol. 2018;17(4):426–441. Multi-center, double-blind, vehicle-controlled clinical trial. 44 subjects enrolled; 42 completed; 12-week evaluation. Products tested: 2-Minute Reveal Masque, 24/7 Barrier Balance Cream, and 8-in-1 BioSerum (Clinical Power Trio).

How it works

Eight Serums in One Formula

Now that you've seen what it does, here's why.

Your body has always known how to build fresh, healthy skin. It does this through natural molecules called defensins. As you age, your body produces fewer of them. The BioSerum delivers patented Age-Repair Defensins® peptides directly to your skin — restoring a process that was already yours.

01

Firmness & lift

Supports your skin's natural collagen for visibly firmer, more lifted skin over time.

02

Retinol alternative

Anti-aging results comparable to retinol without the irritation or sun sensitivity.

03

Antioxidant shield

Protects against environmental damage with a powerful blend that combats free radicals.

04

Brightening

Niacinamide soothes, hydrates, and brightens overall skin tone for a more even complexion.

05

Deep hydration

Hyaluronic acid draws moisture in for smooth, plump, dewy-looking hydration.

06

Calming & soothing

A proprietary blend of natural soothing ingredients calms even the most sensitive skin.

07

Wrinkle smoothing

Advanced peptides target fine lines and deep wrinkles in critical aging areas.

08

Cellular renewal

Plant-based enzymes support DNA repair and restore the skin's natural resilience.

Full Ingredient List — 8-in-1 BioSerum PRO

▾

Water (Aqua), Cyclopentasiloxane, Glycerin, Niacinamide, Sinorhizobium Meliloti Ferment Filtrate, Octyldodecanol, Dimethicone, Polysorbate 20, Dimethicone/Vinyl Dimethicone Crosspolymer, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phospholipids, Alpha-Defensin 5 (sh-Oligopeptide-109 SP), Beta-Defensin 3 (sh-Oligopeptide-108 SP), Palmitoyl Tripeptide-38, Sodium Hyaluronate, Arabidopsis Thaliana Extract, Ribes Nigrum (Black Currant) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Helianthus Annuus (Sunflower) Seed Oil, Ergothioneine, Tocopheryl Acetate, Ubiquinone, Rosmarinus Officinalis (Rosemary) Leaf Extract, Leuconostoc/Radish Root Ferment Filtrate, Tocopherol, Albumin, l-Alanyl-l-Glutamine, Cetyl Hydroxyethylcellulose, Lecithin, Hydroxypropyl Cyclodextrin, Epigallocatechin Gallatyl Glucoside, Phytic Acid, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Sodium Chloride. [ 1-102-1 ]

How to use

Simple. Three Steps. Morning and Night.

1

Cleanse

Start with 1-Step Multi-Cleanse to gently remove debris and prepare your skin.

Morning & evening

2

Moisturize

Apply 1-2 pumps of 24/7 Barrier Balance Cream to your face. Add Eye or Neck cream if using. Wait 30 seconds.

Morning & evening

3

Finish with BioSerum

1-2 pumps on your face. A second pump on your neck. Always the last step. Eight serums working together.

Always last — completes your routine

Why last? The BioSerum forms a protective barrier on the skin's surface, locking in everything beneath it and preventing moisture loss. Follow with sunscreen in the morning.

SS

“I encourage patients who are undergoing office-based skin treatments to use DefenAge before and after those procedures. The 8-in-1 BioSerum primes their skin to respond more quickly and robustly.”

Steven Swengel, MD, FAAD

Dermatologist, Silicon Valley, CA

Available exclusively in-office

Ready to See the Difference?

The 8-in-1 BioSerum PRO Exclusive is available only through authorized medical aesthetic providers. Find one near you to start your journey back to the skin you remember.

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MADE BY DEFENAGE

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6-character code printed on the bottom of the bottle.